abstract：:Great interest was aroused by reports, based on microsatellite markers, of high levels of statistically significant long-range and nonsyntenic linkage disequilibrium (LD) in livestock. Simulation studies showed that this could result from population family structure. In contrast, recent SNP-based studies of livestock ...

journal_title：Genetics

authors： Lipkin E,Straus K,Stein RT,Bagnato A,Schiavini F,Fontanesi L,Russo V,Medugorac I,Foerster M,Sölkner J,Dolezal M,Medrano JF,Friedmann A,Soller M

更新日期：2009-02-01 00:00:00

abstract：:We examined the prevalence of interactions between pairs of short chromosomal regions from one species (Solanum habrochaites) co-introgressed into a heterospecific genetic background (Solanum lycopersicum). Of 105 double introgression line (DIL) families generated from a complete diallele combination of 15 chromosomal...

journal_title：Genetics

authors： Moyle LC,Nakazato T

更新日期：2009-01-01 00:00:00

abstract：:A major challenge in undergraduate life science curricula is the continual evaluation and development of courses that reflect the constantly shifting face of contemporary biological research. Synthetic biology offers an excellent framework within which students may participate in cutting-edge interdisciplinary researc...

journal_title：Genetics

authors： Dymond JS,Scheifele LZ,Richardson S,Lee P,Chandrasegaran S,Bader JS,Boeke JD

更新日期：2009-01-01 00:00:00

abstract：:Mutagenic DNA repair (MDR) employs low-fidelity DNA polymerases capable of replicating past DNA lesions resulting from exposure to high-energy ultraviolet radiation (UVR). MDR confers UVR tolerance and activation initiates a transient mutator phenotype that may provide opportunities for adaptation. To investigate the ...

journal_title：Genetics

authors： Weigand MR,Sundin GW

更新日期：2009-01-01 00:00:00

abstract：:Over one-third of human genome sequence is a product of non-LTR retrotransposition. The retrotransposon that currently drives this process in humans is the highly abundant LINE-1 (L1) element. Despite the ubiquitous nature of L1's in mammals, we still lack a complete mechanistic understanding of the L1 replication cyc...

journal_title：Genetics

authors： Dong C,Poulter RT,Han JS

更新日期：2009-01-01 00:00:00

abstract：:We have created a resource to rapidly map genetic traits to specific chromosomes in yeast. This mapping is done using a set of 16 yeast strains each containing a different chromosome with a conditionally functional centromere. Conditional centromere function is achieved by integration of a GAL1 promoter in cis to cent...

journal_title：Genetics

authors： Reid RJ,Sunjevaric I,Voth WP,Ciccone S,Du W,Olsen AE,Stillman DJ,Rothstein R

更新日期：2008-12-01 00:00:00

abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...

journal_title：Genetics

authors： Desai MM,Plotkin JB

更新日期：2008-12-01 00:00:00

abstract：:The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and mapped two of the mu...

journal_title：Genetics

authors： Acharya SN,Many AM,Schroeder AP,Kennedy FM,Savytskyy OP,Grubb JT,Vincent JA,Friedle EA,Celerin M,Maillet DS,Palmerini HJ,Greischar MA,Moncalian G,Williams RS,Tainer JA,Zolan ME

更新日期：2008-12-01 00:00:00

abstract：:Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity o...

journal_title：Genetics

authors： Drummond-Barbosa D

更新日期：2008-12-01 00:00:00

abstract：:The conserved histone variant H2A.Z fulfills many functions by being an integral part of the nucleosomes placed at specific regions of the genome. Telomeres cap natural ends of chromosomes to prevent their recognition as double-strand breaks. At yeast telomeres, H2A.Z prevents the spreading of silent chromatin into pr...

journal_title：Genetics

authors： Rong YS

更新日期：2008-12-01 00:00:00

abstract：:Dissecting the genes involved in complex traits can be confounded by multiple factors, including extensive epistatic interactions among genes, the involvement of epigenetic regulators, and the variable expressivity of traits. Although quantitative trait locus (QTL) analysis has been a powerful tool for localizing the ...

journal_title：Genetics

authors： Burgess-Herbert SL,Cox A,Tsaih SW,Paigen B

更新日期：2008-12-01 00:00:00

abstract：:Several quantitative trait loci (QTL) mapping strategies can successfully identify major-effect loci, but often have poor success detecting loci with minor effects, potentially due to the confounding effects of major loci, epistasis, and limited sample sizes. To overcome such difficulties, we used a targeted backcross...

journal_title：Genetics

authors： Sinha H,David L,Pascon RC,Clauder-Münster S,Krishnakumar S,Nguyen M,Shi G,Dean J,Davis RW,Oefner PJ,McCusker JH,Steinmetz LM

更新日期：2008-11-01 00:00:00

abstract：:The regulation of chemoreceptor (CR) gene expression by environmental signals and internal cues may contribute to the modulation of multiple physiological processes and behavior in Caenorhabditis elegans. We previously showed that KIN-29, a homolog of salt-inducible kinase, acts in sensory neurons to regulate the expr...

journal_title：Genetics

authors： van der Linden AM,Wiener S,You YJ,Kim K,Avery L,Sengupta P

更新日期：2008-11-01 00:00:00

abstract：:Gametes are produced in plants through mitotic divisions in the haploid gametophytes. We investigated the role of EXPORTIN1 (XPO1) genes during the development of both female and male gametophytes of Arabidopsis. Exportins exclude target proteins from the nucleus and are also part of a complex recruited at the kinetoc...

journal_title：Genetics

authors： Blanvillain R,Boavida LC,McCormick S,Ow DW

更新日期：2008-11-01 00:00:00

abstract：:Protein E, the lysis protein of bacteriophage phiX174, is a specific inhibitor of MraY, the phospho-MurNAc-pentapeptide translocase that catalyzes the synthesis of lipid I in the conserved pathway for peptidoglycan biosynthesis. The original evidence for this inhibition was the isolation of two spontaneous E-resistanc...

journal_title：Genetics

authors： Zheng Y,Struck DK,Bernhardt TG,Young R

更新日期：2008-11-01 00:00:00

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00

abstract：:Despite its importance to agriculture, the genetic basis of heterosis is still not well understood. The main competing hypotheses include dominance, overdominance, and epistasis. NC design III is an experimental design that has been used for estimating the average degree of dominance of quantitative trait loci (QTL) a...

journal_title：Genetics

authors： Garcia AA,Wang S,Melchinger AE,Zeng ZB

更新日期：2008-11-01 00:00:00

abstract：:Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations...

journal_title：Genetics

authors： Alcazar RM,Lin R,Fire AZ

更新日期：2008-11-01 00:00:00

abstract：:Identifying loci under natural selection from genomic surveys is of great interest in different research areas. Commonly used methods to separate neutral effects from adaptive effects are based on locus-specific population differentiation coefficients to identify outliers. Here we extend such an approach to estimate d...

journal_title：Genetics

authors： Foll M,Gaggiotti O

更新日期：2008-10-01 00:00:00

abstract：:Critically shortened telomeres can be subjected to DNA repair events that generate end-to-end chromosome fusions. The resulting dicentric chromosomes can enter breakage-fusion-bridge cycles, thereby impeding elucidation of the structures of the initial fusion events and a mechanistic understanding of their genesis. Cu...

journal_title：Genetics

authors： Lowden MR,Meier B,Lee TW,Hall J,Ahmed S

更新日期：2008-10-01 00:00:00

abstract：:Previous association analyses showed that variation at major regulatory genes contributes to standing variation for complex traits in Balsas teosinte, the progenitor of maize. This study expands our previous association mapping effort in teosinte by testing 123 markers in 52 candidate genes for association with 31 tra...

journal_title：Genetics

authors： Weber AL,Briggs WH,Rucker J,Baltazar BM,de Jesús Sánchez-Gonzalez J,Feng P,Buckler ES,Doebley J

更新日期：2008-10-01 00:00:00

abstract：:Pigmentation is a rapidly evolving trait that can play important roles in mimicry, sexual selection, thermoregulation, and other adaptive processes in many groups of animals. In Drosophila, pigmentation can differ dramatically among closely related taxa, presenting a good opportunity to dissect the genetic changes und...

journal_title：Genetics

authors： Ng CS,Hamilton AM,Frank A,Barmina O,Kopp A

更新日期：2008-09-01 00:00:00

abstract：:We present a two-part system for conditional FLP-out of FRT-flanked sequences in Caenorhabditis elegans to control gene activity in a spatially and/or temporally regulated manner. Using reporters, we assess the system for efficacy and demonstrate its use as a cell lineage marking tool. In addition, we construct and te...

journal_title：Genetics

authors： Voutev R,Hubbard EJ

更新日期：2008-09-01 00:00:00

abstract：:I have studied nucleotide polymorphism and linkage disequilibrium using multilocus data from 77 fragments, with an average length of fragments of 550 bp, in the deciduous tree Populus tremula (Salicaceae). The frequency spectrum across loci showed a modest excess of mutations segregating at low frequency and a marked ...

journal_title：Genetics

authors： Ingvarsson PK

更新日期：2008-09-01 00:00:00

abstract：:SNAP receptor (SNARE) and Sec1/Munc18 (SM) proteins are required for all intracellular membrane fusion events. SNAREs are widely believed to drive the fusion process, but the function of SM proteins remains unclear. To shed light on this, we screened for dominant-negative mutants of yeast Sec1 by random mutagenesis of...

journal_title：Genetics

authors： Boyd A,Ciufo LF,Barclay JW,Graham ME,Haynes LP,Doherty MK,Riesen M,Burgoyne RD,Morgan A

更新日期：2008-09-01 00:00:00

abstract：:Loss or gain of whole chromosomes, or parts of chromosomes, is found in various pathological conditions, such as cancer and aneuploidy, and results from the missegregation of chromosomes during cellular division or abnormal mitotic recombination. We introduce a novel strategy for determining the consequences of segmen...

journal_title：Genetics

authors： Duchon A,Besson V,Pereira PL,Magnol L,Hérault Y

更新日期：2008-09-01 00:00:00

abstract：:The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have...

journal_title：Genetics

authors： Qian W,Zhang J

更新日期：2008-08-01 00:00:00

abstract：:Genes expressed in testes are critical to male reproductive success, affecting spermatogenesis, sperm competition, and sperm-egg interaction. Comparing the evolution of testis proteins at different taxonomic levels can reveal which genes and functional classes are targets of natural and sexual selection and whether th...

journal_title：Genetics

authors： Turner LM,Chuong EB,Hoekstra HE

更新日期：2008-08-01 00:00:00

abstract：:Microsatellite markers are extensively used to evaluate genetic diversity in natural or experimental evolving populations. Their high degree of polymorphism reflects their high mutation rates. Estimates of the mutation rates are therefore necessary when characterizing diversity in populations. As a complement to the c...

journal_title：Genetics

authors： Raquin AL,Depaulis F,Lambert A,Galic N,Brabant P,Goldringer I

更新日期：2008-08-01 00:00:00

abstract：:Seed component structures were grouped into maternal and offspring (embryo and endosperm) tissues to characterize a dormancy quantitative trait locus (QTL) for tissue-specific function using a marker-assisted genetic approach. The approach was devised to test if genotypic/allelic frequencies of a marker tightly linked...

journal_title：Genetics

authors： Gu XY,Turnipseed EB,Foley ME

更新日期：2008-08-01 00:00:00

abstract：:Mapping of expression quantitative trait loci (eQTL) is a powerful means for elucidating the genetic architecture of gene regulation. Yet, eQTL mapping has not been applied toward investigating the regulation architecture of genes involved in the process of population divergence, ultimately leading to speciation event...

journal_title：Genetics

authors： Derome N,Bougas B,Rogers SM,Whiteley AR,Labbe A,Laroche J,Bernatchez L

更新日期：2008-08-01 00:00:00

abstract：:The phenomenon of heterosis describes the increased agronomic performance of heterozygous F(1) plants compared to their homozygous parental inbred plants. Heterosis is manifested during the early stages of root development in maize. The goal of this study was to identify nonadditive gene expression in primary roots of...

journal_title：Genetics

authors： Hoecker N,Keller B,Muthreich N,Chollet D,Descombes P,Piepho HP,Hochholdinger F

更新日期：2008-07-01 00:00:00

abstract：:When a local colonization in a new niche occurs, the new derived population should be subject to different selective pressures from that in the original parental population; consequently it is likely that many loci will be subject to directional selection. In such a quick adaptation event through environmental changes...

journal_title：Genetics

authors： Innan H,Kim Y

更新日期：2008-07-01 00:00:00

abstract：:Many data sets one could use for population genetics contain artifactual sites, i.e., sequencing errors. Here, we first explore the impact of such errors on several common summary statistics, assuming that sequencing errors are mostly singletons. We thus show that in the presence of those errors, estimators of can be ...

journal_title：Genetics

authors： Achaz G

更新日期：2008-07-01 00:00:00

abstract：:Loss of heterozygosity (LOH) can be a driving force in the evolution of mitotic/somatic diploid cells, and cellular changes that increase the rate of LOH have been proposed to facilitate this process. In the yeast Saccharomyces cerevisiae, spontaneous LOH occurs by a number of mechanisms including chromosome loss and ...

journal_title：Genetics

authors： Andersen MP,Nelson ZW,Hetrick ED,Gottschling DE

更新日期：2008-07-01 00:00:00

abstract：:We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) w...

journal_title：Genetics

authors： Niculita-Hirzel H,Stöck M,Perrin N

更新日期：2008-07-01 00:00:00

abstract：:The formation and stability of epigenetically regulated chromatin is influenced by DNA replication and factors that modulate post-translational modifications on histones. Here we describe evidence that PCNA can affect silencing in Saccharomyces cerevisiae by facilitating deposition of H3 K56ac onto chromosomes. We pro...

journal_title：Genetics

authors： Miller A,Yang B,Foster T,Kirchmaier AL

更新日期：2008-06-01 00:00:00

abstract：:Triose phosphate isomerase (TPI) deficiency glycolytic enzymopathy is a progressive neurodegenerative condition that remains poorly understood. The disease is caused exclusively by specific missense mutations affecting the TPI protein and clinically features hemolytic anemia, adult-onset neurological impairment, degen...

journal_title：Genetics

authors： Seigle JL,Celotto AM,Palladino MJ

更新日期：2008-06-01 00:00:00

abstract：:Genotype by environment interactions (GEI) play a major part in shaping the genetic architecture of quantitative traits and are confounding factors in genetic studies, for example, in attempts to associate genetic variation with disease susceptibility. It is generally not known what proportion of phenotypic variation ...

journal_title：Genetics

authors： Sambandan D,Carbone MA,Anholt RR,Mackay TF

更新日期：2008-06-01 00:00:00

abstract：:Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

journal_title：Genetics

authors： Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

更新日期：2008-06-01 00:00:00